The register

Evidence Timeline

Every signal, synthesis, and pattern across the five domains, plotted as it landed — the cross-domain convergences made visible

145 signals published between May 2026 and October 2026, plotted by date across five clinical domains, with 18 cross-domain patterns marked in the month each first appeared.MAYJUNJULMonthly review, edition 1 — Training posts committed, allocation undecided: this month's central workforce tensionED. 1AUGMonthly review, edition 2 — Deprivation and rurality are active drivers of worse outcomes — and AI clinical tools risk adding a new oneED. 2SEPMonthly review, edition 3 — Virtual wards work for who has been tested — not yet for who the NHS most needs to reachED. 3OCTMonthly review, edition 4 — Digital design makes community care more reliable; what it does to the patient's time is still unmeasuredED. 4NOV22 May 2026 — Ceftriaxone use for community bloodstream infections is associated with tripled thirty-day mortality22 May 2026 — Earlier specialist palliative involvement halves acute hospitalisation at end of life — confirmed across cancer, heart failure, and two health systems22 May 2026 — NEWS2 performs barely above chance as a readmission predictor on NHS virtual wards12 Jun 2026 — First NHS England corridor care dataset: 2,940 patients daily in clinically inappropriate settings12 Jun 2026 — Home exercise rehabilitation for frailty after hospital discharge: the HERO trial12 Jun 2026 — Specialist palliative care coding in NHS primary care: too sparse to monitor19 Jun 2026 — Advance care planning reached fewer than 1 in 6 severely frail patients in one hospital cohort19 Jun 2026 — OPAT screening redirected a third of declined referrals to oral therapy: 13,909 home days19 Jun 2026 — VCSE home frailty prevention cut unplanned admissions 35% but did not improve independence26 Jun 2026 — Ceftriaxone associated with threefold mortality increase in MSSA bloodstream infections: implications for OPAT prescribing26 Jun 2026 — Hospital-at-Home preserves physical activity in acute illness: a randomised clinical trial26 Jun 2026 — NEWS2 shows poor predictive accuracy for deterioration on virtual wards3 Jul 2026 — Activity- and exercise-based home rehabilitation improves daily function in older adults, meta-analysis finds3 Jul 2026 — Multiple long-term conditions cut year-one recovery from COVID-19 hospitalisation by a third, UK cohort finds3 Jul 2026 — Structured coding of dying patients linked to far higher advance care planning and community death rates, NHS audit finds5 Jul 2026 — Extended home exercise after acute admission does not improve quality of life in older people with frailty, HERO trial finds10 Jul 2026 — Carer resourcing, not clinical need, shapes advance care planning gaps in dementia10 Jul 2026 — Extended-interval dosing protocol completes IV antibiotic course in three visits10 Jul 2026 — Newer composite frailty tools outperform guideline-endorsed scales, study finds17 Jul 2026 — A fifth of sepsis patients develop new-onset frailty by discharge, registry study finds17 Jul 2026 — Geriatric rehabilitation lacks a common core, systematic review finds17 Jul 2026 — Home deaths best match patient preference, but specialist units deliver better pain control, Canadian cohort finds17 Jul 2026 — Individualised exercise programme improves balance and postural control in older adults, trial finds17 Jul 2026 — Internet-delivered psychological therapy improves quality of life in persistent physical symptoms, trial finds17 Jul 2026 — Meta-analysis confirms exercise-based rehabilitation eases depression in rheumatoid arthritis17 Jul 2026 — Pharmacist involvement in OPAT teams cuts prescribing errors, meta-analysis finds17 Jul 2026 — Qualifying care-home nursing staff in palliative care improves specialist contact and pain management, trial finds17 Jul 2026 — Reablement-based home rehabilitation shows weak evidence of benefit, meta-analysis finds17 Jul 2026 — Specialist screening before OPAT referral avoided almost 14,000 inpatient days over three years, audit finds17 Jul 2026 — Telehome palliative care improves access and continuity, but success hinges on digital readiness, review finds17 Jul 2026 — World Stroke Organisation issues new scientific statement on vascular cognitive impairment24 Jul 2026 — Brief six-domain cognitive screen validated for use in acute stroke, UK study finds24 Jul 2026 — Crisis-response models for older people need common commissioning design principles, review finds24 Jul 2026 — Feasibility trial tests giving physiotherapists individual feedback to standardise MSK referral decisions24 Jul 2026 — Meta-analysis finds remote cardiac rehabilitation matches or exceeds centre-based care for heart failure patients24 Jul 2026 — Multicentre cohort identifies a distinct vulnerability subgroup after home return from severe brain injury24 Jul 2026 — Nearly half of NHS hospital physiotherapists report losing rehabilitation space, survey finds24 Jul 2026 — Paramedic-delivered end-of-life protocol linked to far fewer emergency visits and more home deaths, Finnish cohort finds24 Jul 2026 — PICCs carry far fewer complications than midline catheters in outpatient antimicrobial therapy, US cohort finds24 Jul 2026 — Systematic review finds telerehabilitation a comparable alternative to centre-based cardiac rehabilitation after acute coronary syndrome24 Jul 2026 — Systematic review sets out what makes advance care planning work in nursing homes24 Jul 2026 — Vocational rehabilitation trial finds no benefit on work limitations, and mixed results on retention and cost31 Jul 2026 — Brief GP-delivered psychological intervention improves quality of life a year after ICU discharge, trial finds31 Jul 2026 — Earlier specialist palliative contact roughly halves end-of-life hospitalisation in pancreatic cancer, national Finnish cohort finds31 Jul 2026 — Ethnic minority patients more likely to enter palliative care via specialist referral, national cohort study finds31 Jul 2026 — International researchers propose standardised outcome to fix inconsistent cognitive-outcome reporting after stroke and cardiac care31 Jul 2026 — Largely unsupervised balance training nearly halves fall rate in community-dwelling older adults, trial finds31 Jul 2026 — Nearly a third of older adults with severe breathlessness are lonely, national English cohort finds31 Jul 2026 — Reproducible case-finding rule identifies frequent-attender frail patients for proactive assessment7 Aug 2026 — Adding primary-care rehabilitation to device-aided Parkinson's therapy improves motor-skill maintenance, small RCT finds7 Aug 2026 — Component-level meta-analysis finds social support and behavioural activation outperform specialist techniques in non-specialist-delivered mental health care7 Aug 2026 — Day-hospital long-acting antibiotic pathways show strong real-world clinical success, though the economic case remains modelled rather than proven7 Aug 2026 — Hospital at Home policies risk leaving behind the dementia patients who could benefit most7 Aug 2026 — Only a quarter of hospitalised patients in large US health system had a documented surrogate decision-maker, audit finds7 Aug 2026 — Outer regional areas set to carry almost double their population share of unmet palliative care need, Australian workforce model finds7 Aug 2026 — Phone-based frailty screening matches clinical scale accuracy without internet or in-person assessment7 Aug 2026 — Physiotherapy and occupational therapy staffing in day services was associated with slower functional decline over two years, Japanese cohort finds7 Aug 2026 — Preferred place of death tracks public understanding of palliative care, national Swedish survey finds7 Aug 2026 — Same-day emergency care shows markedly lower mortality than short-stay admission, but the authors caution this may reflect patient selection7 Aug 2026 — Scoping review catalogues 27 interventions to improve advance care planning among structurally vulnerable populations14 Aug 2026 — Advance care planning uptake in ALS has risen over a decade but remains held back by cognitive impairment14 Aug 2026 — Blood-based biomarkers materially change diagnostic confidence in memory clinic decision-making14 Aug 2026 — Earlier specialist palliative care contact halves in-hospital deaths in colorectal cancer, though most deaths still occur in hospital14 Aug 2026 — Education alone underperforms exercise for patellofemoral pain, but professional-led education matches it by medium term14 Aug 2026 — Five-year study finds post-stroke fatigue follows four distinct trajectories, not a uniform decline14 Aug 2026 — Major Cochrane update on stroke dysphagia therapy adds 140 trials, reaffirms behavioural and electrical stimulation as first line14 Aug 2026 — Multicomponent interventions outperform single reminders for raising advance care plan completion in primary care14 Aug 2026 — National physiotherapy workforce survey signals a capacity warning against NICE-mandated rehabilitation intensity14 Aug 2026 — Nearly half of new psychoactive prescribing after intensive care discharge lacks a documented diagnosis14 Aug 2026 — Probenecid-boosted dosing offers a stability-compliant route to intravenous amoxicillin for community antibiotic therapy14 Aug 2026 — Retest effects in serial cognitive testing can mask a year or more of genuine age-related decline14 Aug 2026 — Validated triage tool for same-day emergency care outperforms existing scores in a deprived urban population21 Aug 2026 — £343m expansion of community mental health centres will only work if staffed by psychologists, professional body warns21 Aug 2026 — Community nursing time per palliative patient fell by two-thirds over a decade even as referrals rose, national data show21 Aug 2026 — Exercise improves short-term function in frail older adults but its effect on actual falls remains unproven, meta-analysis finds21 Aug 2026 — Inpatient stroke rehabilitation is near-universal across Europe, but community and telerehabilitation provision lags well behind, survey finds21 Aug 2026 — Landmark African trial finds early oral step-down non-inferior to prolonged IV antibiotics for severe childhood pneumonia21 Aug 2026 — Memory clinic patient volumes more than doubled over 25 years as referral thresholds broadened, national survey finds21 Aug 2026 — Non-immersive exergames and remote exercise show the most consistent cognitive benefit for older adults, network meta-analysis finds21 Aug 2026 — OPAT coordination consistency depends on a designated lead and checklist process, not on clinical suitability, US study finds21 Aug 2026 — People with ADHD have significantly poorer outcomes from standard NHS talking therapies, large cohort study finds21 Aug 2026 — Rural palliative care access breaks down as a pathway and workforce problem, not simply a shortage of beds, systematic review finds21 Aug 2026 — Six mechanisms determine whether mobile health improves home-based palliative care, realist review finds21 Aug 2026 — Telerehabilitation matches in-person stroke therapy for arm recovery only when dose is matched, systematic review finds28 Aug 2026 — Adjunctive electrical stimulation speeds recovery of oral intake in acute stroke dysphagia, small trial finds28 Aug 2026 — Behaviour-change stewardship bundle nearly doubles appropriate-duration antibiotic prescribing in OPAT for urinary tract infection28 Aug 2026 — Clinical Frailty Scale predicts outcomes in elderly heart failure patients, meta-analysis confirms28 Aug 2026 — Competent initial assessment, not the number of quality indicators reported, predicts OPAT readmission risk, scoping review finds28 Aug 2026 — Emergency-department-embedded geriatric assessment discharges most older patients home with hospital-at-home support rather than admission28 Aug 2026 — Implementation capacity, not treatment efficacy, is the primary barrier to delivering high-intensity stroke rehabilitation, international roundtable concludes28 Aug 2026 — Large English trial finds Open Dialogue crisis care cuts psychiatric admission and re-referral, despite no effect on relapse28 Aug 2026 — Multidisciplinary consensus sets out age-adjusted opioid prescribing standard for chronic pain in older adults28 Aug 2026 — Only a quarter of international hospital-at-home admission-avoidance models use validated frailty measures, scoping review finds28 Aug 2026 — People with opioid use disorder have equivalent palliative care needs but markedly worse access, scoping review finds28 Aug 2026 — Placebo-controlled trial finds no benefit from pilocarpine drops for dry mouth in frail and life-limited patients28 Aug 2026 — Rural hospice patients in the US receive less intensive support and rely more on unpaid family caregiving than urban peers4 Sep 2026 — A five-year, 887-patient study finds high satisfaction with telemedicine-based hospital-at-home care, but does not measure whether it saves clinical resource4 Sep 2026 — A national accessibility mapping method shows hospice access declining sharply outside Germany's cities, and offers a transferable way to measure it4 Sep 2026 — Apathy after hip fracture surgery independently predicts poorer functional recovery, multicentre study finds4 Sep 2026 — Cochrane review finds little to no evidence that lumbar supports or other assistive devices help chronic low back pain4 Sep 2026 — Digital tools for following up older patients after discharge are feasible and liked, but their effect on readmission remains unproven, systematic review finds4 Sep 2026 — Falls research rarely records the same details twice, systematic review finds, and proposes a standard reporting framework4 Sep 2026 — Fewer than half of older major trauma patients have a documented treatment escalation plan, national UK audit finds4 Sep 2026 — First national survey finds most UK palliative virtual wards still run on phone calls, not technology, and many depend on charity funding4 Sep 2026 — Five factors predict who reattempts suicide within a year of a first attempt, large Spanish cohort finds4 Sep 2026 — UK review finds almost no quality-assured patient education materials exist for home intravenous antibiotic therapy4 Sep 2026 — Which components of talking therapy actually help? Large meta-analysis identifies the ones that work — and two that may not4 Sep 2026 — Who engages with, and responds to, CBT for psychosis remains largely unpredictable, systematic review finds11 Sep 2026 — Dual-comparator Taiwan cohort strengthens the evaluation case for emergency-department-initiated OPAT11 Sep 2026 — Frailty independently predicts functional decline during hospital admission, meta-analysis finds11 Sep 2026 — In an operating virtual hospital, carers absorbed the technical work — most of all where patients had low digital literacy, language barriers or reduced mobility11 Sep 2026 — National audit puts hard numbers behind the claim that hospital flow is failing on delivery, not diagnosis18 Sep 2026 — A formal verification programme, not guidance alone, raised surgical vulnerability assessment18 Sep 2026 — An appraised evidence base for managing frailty in the emergency department18 Sep 2026 — Better goals-of-care documentation does not reliably mean better outcomes18 Sep 2026 — Home antibiotic therapy shows lower mortality than hospital care for infective endocarditis18 Sep 2026 — Israel's national hospital-at-home programme reports lower mortality than hospital admission18 Sep 2026 — Psychology embedded in primary care improves access, but the workforce strain is real too18 Sep 2026 — Rural access and staff technology support are the standing barriers to hospital-at-home, Canadian workshops find18 Sep 2026 — Taiwan's national insurer reports lower costs for nursing-home residents treated at home18 Sep 2026 — Telehealth works best as a hybrid, not a stand-alone substitute, rural scoping review finds18 Sep 2026 — UK day-surgery guidance names frailty explicitly for the first time at this scale25 Sep 2026 — Frailty-targeted cardiac rehabilitation improves function, not survival, meta-analysis finds25 Sep 2026 — Methylphenidate eases depressive symptoms in palliative care, meta-analysis finds, though evidence remains uncertain25 Sep 2026 — Nine in ten UK palliative care researchers want to continue the work; fewer than seven in ten expect they will be able to25 Sep 2026 — Saudi Arabia's national virtual hospital succeeds as governance, not yet as proven outcomes, policy analysis finds2 Oct 2026 — Earlier recording of a medically-ready-for-discharge date was associated with fewer unnecessary bed days in a US hospital system2 Oct 2026 — In older adults seen by liaison psychiatry, frailty outweighed psychiatric variables in predicting early mortality2 Oct 2026 — Patients with recent homelessness were designated as awaiting alternative care at more than four times the rate of matched comparators in Ontario2 Oct 2026 — Self-administered home antibiotics matched other delivery models in a large UK cohort, with failure risk concentrated in older, multimorbid patients2 Oct 2026 — Six European countries' timely-discharge policies share principles of clear responsibility and resourced community capacity9 Oct 2026 — Digital interventions for chronic musculoskeletal pain show small average gains, with low certainty and no proven superior format9 Oct 2026 — Green health prescribing for older adults: many studies report benefit, few show significant effects, and certainty is low9 Oct 2026 — Home-based exercise rehabilitation in cancer improved fitness and quality of life, with high heterogeneity9 Oct 2026 — No study defined patient time in patient-reported terms: a review of how care burden is measured in cancer16 Oct 2026 — After rehabilitation for brain injury, clinical need was not the dominant influence on whether older adults received community therapy16 Oct 2026 — An app-based integrated-care system with geriatric assessment did not reduce unplanned hospitalisation in older adults with atrial fibrillation16 Oct 2026 — Community palliative care benefit is attributed to five interacting mechanisms, not to the site of care16 Oct 2026 — Home-based primary care for veterans with dementia was associated with less emergency department use in an instrumental-variable analysis16 Oct 2026 — Moving cardiac rehabilitation into 21 Danish municipalities halved median travel distance and narrowed geographic and educational gaps in uptake16 Oct 2026 — Seven outpatient parenteral antimicrobial therapy guidelines vary widely in methodological and reporting quality16 Oct 2026 — Telerehabilitation and face-to-face rehabilitation for chronic low back pain did not differ significantly, but the evidence is too uncertain to show equivalence23 Oct 2026 — A national audit finds only 16% of people diagnosed with severe frailty in England had the medication review the GP contract requires23 Oct 2026 — Resistance exercise has the clearest pooled signal on frailty scores, but the range of true effects includes no benefit23 Oct 2026 — The electronic frailty index shows a graded association with mortality, but not that identifying frailty changes what happens nextVF-P1 · provisional — Earlier specialist input → better outcomesVF-P2 · provisional — Information infrastructure as clinical necessityVF-P3 · provisional — Community settings structurally underequippedVF-P4 · provisional — Acute-designed shortcuts carry material risk in community settingsVF-P5 · qualified — Sarcopenia as measurable treatable driver of frailty declineVF-P6 · provisional — Converging mandates for community AHP investmentVF-P7 · provisional — Mandate-capacity tensionVF-P8 · qualified — Structured identification and coding outperform usual identification practiceVF-P9 · discarded — Process and regulatory simplification as a capacity-recovery lever distinct from headcount expansionVF-P10 · provisional — Identification-tooling as a capacity substituteVF-P11 · discarded — Process-simplification-as-capacity-lever meets the international benchmarkVF-P12 · qualified — Digital exclusion and carer capacity are the binding constraint on who benefits from remote and home-based care modelsVF-P13 · provisional — Structural and measurement fidelity at the point of handover, not the underlying clinical evidence, is the binding constraint on delivered benefitVF-P14 · provisional — Real-world remote patient monitoring can redistribute rather than reduce clinical workload, without a matching outcome gainVF-P15 · provisional — A capacity or equity safeguard is identified with precision and then left unbuiltVF-P16 · provisional — Process measures move; patient-outcome measures are flat, untested or unmeasuredVF-P17 · provisional — Remote and virtual care reaches dispersed populations where the model is built around the distance problem, and loses reliability where a ward-validated device is sent homeVF-P18 · provisional — Social and material disadvantage lengthens time in the system and lowers recovery
Signal Spans domains Pattern, established Qualified Provisional Discarded

The record, month by month

The same record as the Loom, in words, newest first: each month's editions and weekly syntheses, the signals that crossed domains, and every move in the pattern register. A pattern's full history is on its own page.

October 202619 signals · 4 syntheses

Pattern register
  • VF-P1 Earlier specialist input → better outcomes re-graded established → provisional
  • VF-P2 Information infrastructure as clinical necessity reconfirmed; re-graded established → provisional
  • VF-P3 Community settings structurally underequipped reconfirmed; re-graded established → provisional
  • VF-P4 Acute-designed shortcuts carry material risk in community settings reconfirmed; re-graded established → provisional
  • VF-P5 Sarcopenia as measurable treatable driver of frailty decline downgraded to qualified
  • VF-P6 Converging mandates for community AHP investment downgraded to qualified; re-graded qualified → provisional
  • VF-P7 Mandate-capacity tension re-graded established → provisional
  • VF-P8 Structured identification and coding outperform usual identification practice downgraded to qualified
  • VF-P9 Process and regulatory simplification as a capacity-recovery lever distinct from headcount expansion re-graded provisional → discarded
  • VF-P10 Identification-tooling as a capacity substitute downgraded to qualified; re-graded qualified → provisional
  • VF-P11 Process-simplification-as-capacity-lever meets the international benchmark re-graded provisional → discarded
  • VF-P12 Digital exclusion and carer capacity are the binding constraint on who benefits from remote and home-based care models reconfirmed; re-graded established → qualified
  • VF-P13 Structural and measurement fidelity at the point of handover, not the underlying clinical evidence, is the binding constraint on delivered benefit reconfirmed
  • VF-P14 Real-world remote patient monitoring can redistribute rather than reduce clinical workload, without a matching outcome gain reconfirmed
  • VF-P16 Process measures move; patient-outcome measures are flat, untested or unmeasured entered as provisional
  • VF-P17 Remote and virtual care reaches dispersed populations where the model is built around the distance problem, and loses reliability where a ward-validated device is sent home entered as provisional
  • VF-P18 Social and material disadvantage lengthens time in the system and lowers recovery entered as provisional

September 202630 signals · 4 syntheses

Pattern register
  • VF-P12 Digital exclusion and carer capacity are the binding constraint on who benefits from remote and home-based care models moved to established
  • VF-P13 Structural and measurement fidelity at the point of handover, not the underlying clinical evidence, is the binding constraint on delivered benefit entered as provisional
  • VF-P14 Real-world remote patient monitoring can redistribute rather than reduce clinical workload, without a matching outcome gain entered as provisional
  • VF-P15 A capacity or equity safeguard is identified with precision and then left unbuilt entered as provisional

August 202647 signals · 4 syntheses

Pattern register
  • VF-P8 Structured identification and coding outperform usual identification practice moved to established
  • VF-P10 Identification-tooling as a capacity substitute reconfirmed
  • VF-P12 Digital exclusion and carer capacity are the binding constraint on who benefits from remote and home-based care models entered as provisional

July 202637 signals · 5 syntheses

Pattern register
  • VF-P1 Earlier specialist input → better outcomes reconfirmed
  • VF-P3 Community settings structurally underequipped reconfirmed
  • VF-P7 Mandate-capacity tension reconfirmed
  • VF-P8 Structured identification and coding outperform usual identification practice entered as provisional
  • VF-P9 Process and regulatory simplification as a capacity-recovery lever distinct from headcount expansion entered as provisional
  • VF-P10 Identification-tooling as a capacity substitute entered as provisional
  • VF-P11 Process-simplification-as-capacity-lever meets the international benchmark entered as provisional

June 20269 signals · 3 syntheses

Pattern register
  • VF-P1 Earlier specialist input → better outcomes entered as established
  • VF-P2 Information infrastructure as clinical necessity entered as established
  • VF-P3 Community settings structurally underequipped entered as established
  • VF-P4 Acute-designed shortcuts carry material risk in community settings entered as established
  • VF-P5 Sarcopenia as measurable treatable driver of frailty decline entered as established
  • VF-P6 Converging mandates for community AHP investment entered as established
  • VF-P7 Mandate-capacity tension entered as established